MPDZ Antikörper (AA 388-480) (Cy3)

Produktnummer ABIN1413045

Produktdetails anti-MPDZ Antikörper (Cy3)

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Bindungsspezifität: AA 388-480

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPDZ Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MUPP1/MPDZ

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MPDZ

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Andere Bezeichnung: MUPP1/MPDZ (MPDZ Produkte)

Synonyme: HYC2 antikoerper, MUPP1 antikoerper, AI225843 antikoerper, B930003D11Rik antikoerper, multiple PDZ domain crumbs cell polarity complex component antikoerper, multiple PDZ domain protein antikoerper, Multiple PDZ domain protein antikoerper, inactivation-no-after-potential D protein antikoerper, multiple pdz domain protein, putative antikoerper, MPDZ antikoerper, Mpdz antikoerper, mpz-1 antikoerper, LOC5569990 antikoerper, Smp_168960 antikoerper

Hintergrund:

Synonyms: MPDZ, Multi PDZ domain protein 1, Multi-PDZ domain protein 1, multiple PDZ domain protein, MPDZ_HUMAN.

Background: MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.

Pathways: Synaptic Membrane, Phototransduction