SHC2 Antikörper (AA 161-270) (Cy3)
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- Target Alle SHC2 Antikörper anzeigen
- SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
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Bindungsspezifität
- AA 161-270
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SHC2 Antikörper ist konjugiert mit Cy3
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Applikation
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SHC2/Sck
- Isotyp
- IgG
- Top Product
- Discover our top product SHC2 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2 (SHC2))
- Andere Bezeichnung
- SHC2/Sck (SHC2 Produkte)
- Synonyme
- SCK antikoerper, SHCB antikoerper, SLI antikoerper, 6720466E06 antikoerper, ShcB antikoerper, Sli antikoerper, SHC adaptor protein 2 antikoerper, SHC (Src homology 2 domain containing) transforming protein 2 antikoerper, SHC2 antikoerper, Shc2 antikoerper
- Hintergrund
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Synonyms: Protein Sck, SCK, SH2 domain protein C2, SHC transforming protein 2, SHCB, Src homology 2 domain containing transforming protein C2, SHC2_HUMAN.
Background: Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).
- Pathways
- RTK Signalweg, Neurotrophin Signalübertragung, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, VEGF Signaling
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