ALAS2 Antikörper (HRP)

Produktnummer ABIN1421050

Produktdetails anti-ALAS2 Antikörper (HRP)

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALAS2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ALAS2/ALAS-E

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ALAS2

Target: ALAS2 (Aminolevulinate, delta-, Synthase 2 (ALAS2))

Andere Bezeichnung: ALAS-E (ALAS2 Produkte)

Synonyme: anh1 antikoerper, asb antikoerper, xlsa antikoerper, ALAS-E antikoerper, ALASE antikoerper, ANH1 antikoerper, ASB antikoerper, XLDPP antikoerper, XLEPP antikoerper, XLSA antikoerper, alas-e antikoerper, cb1063 antikoerper, sau antikoerper, sauternes antikoerper, ALAS antikoerper, Alas-2 antikoerper, 5'-aminolevulinate synthase 2 antikoerper, aminolevulinate, delta-, synthase 2 antikoerper, aminolevulinic acid synthase 2, erythroid antikoerper, alas2 antikoerper, ALAS2 antikoerper, Alas2 antikoerper, alas2.L antikoerper

Hintergrund:

Synonyms: 5-aminolevulinate synthase, erythroid-specic, mitochondrial, 5-aminolevulinic acid synthase, ALAS E, ALASE, ANH1, Delta aminolevulinate synthase, XLSA, 5 aminolevulinic acid synthase 2, 5-aminolevulinate synthase 2, 5-aminolevulinate synthase, 5-aminolevulinate synthase 2, Alas 2, ALAS, ALAS E, ALAS, erythroid, ALASE, Aminolevulinate, delta-, synthase 2, Aminolevulinic acid synthase 2, erythroid, ANH1, ASB, Delta ALA synthase 2, Delta ALA synthetase, Delta aminolevulinate synthase 2, Delta aminolevulinate synthase, Erythroid specic ALAS, FLJ93603, XLDPP, XLSA.

Background: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Gen-ID: 212

Pathways: Transition Metal Ion Homeostasis