Calnexin Antikörper (C-Term)

Produktnummer ABIN1440008

Dieser Ziege Polyklonal Antikörper detektiert spezifisch Calnexin in WB, IF, IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Affe, Kaninchen, Meerschweinchen, Schwein, Hamster, Schaf, Huhn, Avian, Pferd, Ziege, Cat und Esel. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für Calnexin Antikörper (C-Term) (ABIN1440008)

Target: Calnexin (CANX)

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Affe, Kaninchen, Meerschweinchen, Schwein, Hamster, Schaf, Huhn, Avian, Pferd, Ziege, Cat, Esel

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Calnexin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Calnexin Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-CANX

Sequenz: KSDAEEDGGT VSQEEEDRKP KAEEDEILNR SPRNRKPRRE

Spezifität: Detects a band of 90 kDa by Western blot in the following human (293A, primary fibroblasts, HaCat, HeLa, HMEC-1, Jurkat, MNT1, U-118, rat (TR-iBRB), mouse (3T3, AtT-20, Hepa, Raw264.7), monkey (COS-7) and canine (D17) whole cell lysates.

Produktmerkmale: Calnexin

Aufreinigung: Epitope affinity purified

Immunogen: Purified recombinant peptide within residues 550 aa to the C-terminus of human CANX produced in E. coli.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:5,000, IF:1:50-1:500, IHC-P:1:200-1:1,000, IHC-F:1:200-1:1,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody solution should be gently mixed before use.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Referenzen für anti-Calnexin Antikörper (ABIN1440008)

Pelkonen, Sato, Reinisalo, Kidron, Tachikawa, Watanabe, Uchida, Urtti, Terasaki: "LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line." in: Molecular pharmaceutics, Vol. 14, Issue 3, pp. 605-613, (2017) (PubMed).

Martins-Marques, Pinho, Zuzarte, Oliveira, Pereira, Sluijter, Gomes, Girao: "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin." in: Journal of extracellular vesicles, Vol. 5, pp. 32538, (2016) (PubMed).

Ribot, Ribeiro, Correia, Sousa, Silva-Santos: "Human ?? thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 5, pp. 2237-43, (2014) (PubMed).

Details zu Calnexin

Target: Calnexin (CANX)

Andere Bezeichnung: CANX

Hintergrund:

Goat polyclonal to CANX (Calnexin) - endoplasmic reticulum (ER) membrane marker. CANX is a member of the calnexin family of molecular chaperones. This protein is a calcium-binding, ER-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.

Calnexin, CALX, CNX, FLJ26570, histocompatibility complex class I antigen binding protein p88, IP90, major histocompatibility complex class I antigen-binding protein p88, MS952, P90 antibody.

Pathways: MAPK Signalweg, Thyroid Hormone Synthesis