Connexin 43/GJA1 Antikörper (C-Term)

Produktnummer ABIN1440034

Produktdetails anti-Connexin 43/GJA1 Antikörper

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Affe, Rind (Kuh), Kaninchen, Huhn, Meerschweinchen, Schwein, Pferd, Schaf, Hamster, Ziege, Avian, Cat, Esel

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Detects endogenous levels of total connexin 43.

Produktmerkmale: Gap junction protein, alpha 1, 43  kDa

Aufreinigung: epitope affinity purified

Immunogen: Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 4 mg/mL

Buffer: Polyclonal antibody supplied as a 200 µL (4 mg/mL) aliquot in PBS, 20 % glycerol and 0.05 % sodium azide

Handhabung: The antibody solution should be gently mixed before use.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For continuous use, store at 2-8 deg,C for one-two days. For extended storage, store in -20 deg,C freezer. Working dilution samples should be discarded if not used within 12 hours.

Referenzen für anti-Connexin 43/GJA1 Antikörper (ABIN1440034)

Martins-Marques, Pinho, Zuzarte, Oliveira, Pereira, Sluijter, Gomes, Girao: "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin." in: Journal of extracellular vesicles, Vol. 5, pp. 32538, (2016) (PubMed).

Martins-Marques, Anjo, Pereira, Manadas, Girão: "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 11, pp. 3040-55, (2016) (PubMed).

Ribeiro-Rodrigues, Catarino, Marques, Ferreira, Martins-Marques, Pereira, Girão: "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4629-41, (2015) (PubMed).

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: CX43 (GJA1 Produkte)

Synonyme: AVSD3 antikoerper, CX43 antikoerper, DFNB38 antikoerper, GJAL antikoerper, HLHS1 antikoerper, HSS antikoerper, ODDD antikoerper, Cx43 antikoerper, AU042049 antikoerper, AW546267 antikoerper, Cnx43 antikoerper, Cx43alpha1 antikoerper, Gja-1 antikoerper, Npm1 antikoerper, connexin43 antikoerper, cx43a1 antikoerper, gja1 antikoerper, zfCx43.3 antikoerper, connexin 43 antikoerper, gja1-A antikoerper, cx43 antikoerper, gjal antikoerper, oddd antikoerper, dfnb38 antikoerper, gap junction protein alpha 1 antikoerper, gap junction protein, alpha 1 antikoerper, connexin 43 antikoerper, gap junction protein alpha 1 L homeolog antikoerper, CONNEXIN 43 protein antikoerper, GJA1 antikoerper, Gja1 antikoerper, cx43 antikoerper, gja1.L antikoerper, gja1 antikoerper, CONNEXIN 43 antikoerper

Hintergrund: Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.
Synonyms: AVSD3, CX43, DFNB38, gap junction protein, alpha 1, 43kDa, GJA1, GJAL HSS, HLHS1, ODDD antibody.
Ensembl identifier: ENSG00000152661

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization