ES1 Protein Homolog (AA 1-281), (full length), (N-Term) Antikörper

Produktnummer ABIN1449175

Produktdetails

Target: ES1 Protein Homolog

Bindungsspezifität: AA 1-281, full length, N-Term

Reaktivität: Ratte

Wirt: Ratte

Klonalität: Monoklonal

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Spezifität: This antibody reacts with rat HES1.

Aufreinigung: Protein G agarose

Immunogen: Full-length rat HES1 (1-281 aa)

Klon: NM1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Antigendetails

Target: ES1 Protein Homolog

Hintergrund: Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I

Gen-ID: 294326

NCBI Accession: NP_001004225

UniProt: P56571