PRPF3 Antikörper

Produktnummer ABIN1449201

Produktdetails anti-PRPF3 Antikörper

Target: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Reaktivität: Human, Maus, Ratte, Hamster

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PRPF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Spezifität: This antibody reacts with Prp3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Hamster, Rat

Aufreinigung: Protein G agarose

Immunogen: Human recombinant full-length GSTPrp3

Klon: 4-00E-003

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu PRPF3

Target: PRPF3 (PRP3 Pre-mRNA Processing Factor 3 Homolog (PRPF3))

Andere Bezeichnung: PRPF3 (PRPF3 Produkte)

Synonyme: HPRP3 antikoerper, HPRP3P antikoerper, wu:fa11f05 antikoerper, PRPF3 antikoerper, PRP3 antikoerper, Prp3p antikoerper, RP18 antikoerper, SNRNP90 antikoerper, 3632413F13Rik antikoerper, PRP3 pre-mRNA processing factor 3 homolog (yeast) antikoerper, pre-mRNA processing factor 3 antikoerper, pre-mRNA processing factor 3 S homeolog antikoerper, PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) antikoerper, prpf3 antikoerper, PRPF3 antikoerper, prpf3.S antikoerper, Prpf3 antikoerper

Hintergrund: Retinitis pigmentosa (RP) is an inheritable disease characterized by progressive retinal degeneration and loss of rod photoreceptor cells, leading to total blindness. Recently three genes responsible for autosomal dominant RP (HPRP3, PRPF31, and PRPC8) have been identified as the human orthologues of the yeast genes PRP3, PRP31, and PRP8, respectively. The removal of introns from nuclear pre-mRNAs occurs on spliceosomes, which consist of 4 small nuclear ribonucleoprotein (snRNP) particles and a number of transiently associated splicing factors. All three PRP (pre-mRNA processing factor) genes are involved in the function of the U4/U6,U5 tri-snRNP, the spliceosome component required for the transition to a catalytically active state. In mammals, the 63 kDa HPRP3 is thought to recruit HPRP4 to the U4/U6 snRNP. In yeast, PRP3 and PRP4 genetically interact, and physical interactions between Prp3p and Prp4p proteins are required for association of Prp3p and Prp4p with U4/U6.Synonyms: HPRP3, PRP3, Pre-mRNA-splicing factor 3, U4/U6 small nuclear ribonucleoprotein Prp3, U4/U6 snRNP 90 kDa protein

Molekulargewicht: 80 kDa

Gen-ID: 9129

NCBI Accession: NP_004689

UniProt: O43395