SIPA1 Antikörper

Produktnummer ABIN1449259

Produktdetails anti-SIPA1 Antikörper

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: This antibody reacts with human SPA-1.

Aufreinigung: Anion exchange column chromatography

Immunogen: Recombinant human SPA-1

Klon: 331-9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu SIPA1

Target: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Andere Bezeichnung: SIPA1 / SPA1 (SIPA1 Produkte)

Synonyme: Spa1 antikoerper, SPA1 antikoerper, signal-induced proliferation-associated 1 antikoerper, Signal peptidase I (leader peptidase I) antikoerper, signal-induced proliferation associated gene 1 antikoerper, SIPA1 antikoerper, sipA1 antikoerper, Sipa1 antikoerper

Hintergrund: SPA-1 , signal-induced proliferation associated gene 1, encodes a 130 kDa protein (p130 SPA-1 ) with a domain related to Rap1 GTPase activating protein (Rap1GAP) at the N-terminus and to PDZ protein interaction domain followed by a leucine zipper motif at the C-terminus. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for other small GTPases. p130 SPA-1 was mostly localized at both the plasma membrane and the perinuclear membranous region co-localizing with Rap1 and Rap2. Expression of SPA-1 and rap1GAP genes tended to be segregate in various tissues, lymphoid and hematopoietic tissues expressing abundant SPA-1 transcript without rap1GAP , while those such as brain, kidney and pancreas exhibiting rap1GAP mRNA with little SPA-1.Synonyms: GTPase-activating protein Spa-1, Signal-induced proliferation-associated protein 1, Sipa-1, Spa-1, p130 SPA-1

Gen-ID: 6494

NCBI Accession: NP_006738

UniProt: Q96FS4

Pathways: Response to Water Deprivation