CD59 Antikörper (FITC)

Produktnummer ABIN1449270

Produktdetails anti-CD59 Antikörper (FITC)

Target: CD59

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD59 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Spezifität: This antibody reacts with human CD59 antigen.

Aufreinigung: Protein A agarose

Immunogen: Human myeloma cell line (RPMI8226)

Klon: WK8

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59 (CD59 Produkte)

Synonyme: 16.3A5 antikoerper, 1F5 antikoerper, EJ16 antikoerper, EJ30 antikoerper, EL32 antikoerper, G344 antikoerper, HRF-20 antikoerper, HRF20 antikoerper, MAC-IP antikoerper, MACIF antikoerper, MEM43 antikoerper, MIC11 antikoerper, MIN1 antikoerper, MIN2 antikoerper, MIN3 antikoerper, MIRL antikoerper, MSK21 antikoerper, p18-20 antikoerper, Cd59a antikoerper, Cd59b antikoerper, MACIP antikoerper, CD59 molecule (CD59 blood group) antikoerper, CD59 molecule antikoerper, CD59 antikoerper, Cd59 antikoerper

Hintergrund: CD59, an 18-20 kDa GPI-anchored glycoprotein, is broadly distributed, present in most tissues, and on all circulating cells. CD59 has been also known as 20 kDa homologous restriction factor (HRF20), membrane attack complex inhibitory factor (MACIF), membrane inhibitor of reactive lysis (MIRL) and protectin. CD59 inhibits the cytolytic activity of complement by binding to C8 and C9 in the assembling of the cytolytic membrane attack complex (MAC), thereby interfering with membrane insertion and pore formation. CD59 and other membrane complement regulatory proteins (CD46 and CD55) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. CD59 also interacts with T cell-restricted glycoprotein CD2 and plays a role in T cell activation.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

Gen-ID: 966

NCBI Accession: NP_000602

UniProt: P13987

Pathways: Komplementsystem