14-3-3 gamma Antikörper (N-Term)

Produktnummer ABIN1449274

Produktdetails anti-14-3-3 gamma Antikörper

Target: 14-3-3 gamma (YWHAG1)

Bindungsspezifität: AA 1-12, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser 14-3-3 gamma Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: This antibody reacts with 14-3-3γ, which the N-terminal Met is removed as a result of acetylated the N-terminal Val, on Western blotting. This antibody does not recognize unprocessed (non-modified) 14-3-3γ.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Aufreinigung: Protein A agarose

Immunogen: KLH-conjugated human 14-3-3gamma N-terminal peptides (1-12 aa)

Klon: KC21

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu 14-3-3 gamma

Target: 14-3-3 gamma (YWHAG1)

Andere Bezeichnung: 14-3-3 Protein gamma (YWHAG1 Produkte)

Hintergrund: The 14-3-3 protein family comprises critical regulatory molecules involved in signaling during cell division, proliferation, and apoptosis. 14-3-3 γ, a subtype of the 14-3-3 family of proteins, was thought to be brain- and neuron-specific. However, 14-3-3 γ was not neuron-specific but also expressed in astrocytes. Endogenous 14-3-3 γ proteins in immature astrocytes appeared filamentous and co-localized with filamentous actin (F-actin). And, 14-3-3 γ proteins play a role in cytoskeletal function during the process of cell division and apoptosis in astrocytes in association with actin. This expression is induced in arterial trauma by cytokines, and suggests that this protein may play an important role in progression of vascular proliferative diseases.Synonyms: KCIP-1, Protein kinase C inhibitor protein 1, YWHAG

Molekulargewicht: 33 kDa

Gen-ID: 7532

NCBI Accession: NP_036611

UniProt: P61981

Pathways: Myometrial Relaxation and Contraction, M Phase