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GRB2 Antikörper (N-Term)
GRB2
Reaktivität: Human, Maus, Ratte
WB
Wirt: Maus
Monoclonal
3F2
unconjugated
Produktnummer ABIN1449302
Produktdetails anti-GRB2 Antikörper
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Target
Alle GRB2 Antikörper anzeigen
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Bindungsspezifität
Alle Epitope für GRB2 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für GRB2 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für GRB2 Antikörper
Maus
Klonalität
Alle Klonalitäten für GRB2 Antikörper
Monoklonal
Konjugat
Alle Konjugate für GRB2 Antikörper
Dieser GRB2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für GRB2 Antikörper
Western Blotting (WB)
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse, Rat
Aufreinigung
Ammonium sulfate precipitation and affinity chromatography on protein A
Immunogen
Recombinant Ash/Grb-2
Klon
3F2
Isotyp
IgG1
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Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Rekonstitution
Restore with 100 μL of distilled water.
Buffer
PBS, 1 mg/mL Sodium azide, 10 mg/mL sucrose
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Details zu GRB2
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Target
GRB2
(Growth Factor Receptor-Bound Protein 2 (GRB2))
Andere Bezeichnung
GRB2 / ASH (GRB2 Produkte )
Synonyme
GRB2 antikoerper, grb2 antikoerper, AA408164 antikoerper, Ash antikoerper, ASH antikoerper, EGFRBP-GRB2 antikoerper, Grb3-3 antikoerper, MST084 antikoerper, MSTP084 antikoerper, NCKAP2 antikoerper, wu:fb18e12 antikoerper, wu:fb34e06 antikoerper, zgc:73077 antikoerper, growth factor receptor bound protein 2 antikoerper, growth factor receptor-bound protein 2 antikoerper, growth factor receptor-bound protein 2b antikoerper, GRB2 antikoerper, grb2 antikoerper, Grb2 antikoerper, grb2b antikoerper
Hintergrund
Grb2 (Growth factor receptor bound protein 2) also known as Ash, is a 25-28 kDa molecule composed of central Src homology (SH2) domain and SH3 domains. Grb2 associates with tyrosine phosphorylated proteins such as EGFR, PDGFR, IRS-1, Shc and Gab1 via its Sh2 domain. The SH3 domain of Grb2 binds to Sos, which stimulates the GTP binding activity of Ras, cause activation of MAP kinase and other signaling pathways. Grb2 is an adaptor protein, which does not have enzymatic activity itself. Grb2 express ubiquitously and has two isoforms.Synonyms: Growth factor receptor-bound protein 2
Gen-ID
2885
NCBI Accession
NP_002077
UniProt
P62993
Pathways
RTK Signalweg , T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Regulation of Actin Filament Polymerization , Hepatitis C , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , EGFR Downregulation
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