PIK3C3 Antikörper (AA 19-49)

Produktnummer ABIN1449618

Produktdetails anti-PIK3C3 Antikörper

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Bindungsspezifität: AA 19-49

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3C3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung: Protein A column, followed by peptide affinity purification.

Immunogen: KLH conjugated synthetic peptide between 19~49 amino acids surrounding Serine 34 of Human PI3KC3

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-PIK3C3 Antikörper (ABIN1449618)

Lacroix Pépin, Chapdelaine, Rodriguez, Tremblay, Fortier: "Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1." in: Molecular human reproduction, Vol. 20, Issue 7, pp. 650-63, (2015) (PubMed).

Eleftheriadis, Pissas, Antoniadi, Liakopoulos, Stefanidis: "Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells." in: Immunology, Vol. 146, Issue 2, pp. 292-300, (2015) (PubMed).

Guess, Ayoob, Chanley, Manley, Cajaiba, Agrawal, Pengal, Pyle, Becknell, Kopp, Ronkina, Gaestel, Benndorf, Smoyer: "Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis." in: PLoS ONE, Vol. 8, Issue 1, pp. e54239, (2013) (PubMed).

Minakami, Maehara, Kamakura, Kumano, Miyano, Sumimoto: "Membrane phospholipid metabolism during phagocytosis in human neutrophils." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 5, pp. 409-24, (2010) (PubMed).

May, Sureban, Lightfoot, Hoskins, Brackett, Postier, Ramanujam, Rao, Wyche, Anant, Houchen: "Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 299, Issue 2, pp. G303-10, (2010) (PubMed).

Details zu PIK3C3

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Andere Bezeichnung: PIK3C3 (PIK3C3 Produkte)

Synonyme: im:7147158 antikoerper, wu:fc13g06 antikoerper, wu:fz51e12 antikoerper, zgc:112016 antikoerper, zgc:113009 antikoerper, VPS34 antikoerper, hVps34 antikoerper, 5330434F23Rik antikoerper, Vps34 antikoerper, phosphatidylinositol 3-kinase catalytic subunit type 3 antikoerper, phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog antikoerper, phosphatidylinositol 3-kinase, catalytic subunit type 3 antikoerper, PIK3C3 antikoerper, pik3c3.L antikoerper, pik3c3 antikoerper, Pik3c3 antikoerper

Hintergrund: PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.Synonyms: PI3-kinase type 3, PI3K type 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, VPS34

Molekulargewicht: 101549 Da

Gen-ID: 5289

NCBI Accession: NP_002638

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagie