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SQSTM1 Antikörper (C-Term)

Name: SQSTM1 Antikörper (C-Term)
SKU: ABIN1449619
Price: 869.85 EUR
Availability: InStock

SQSTM1 Reaktivität: Human WB, IF, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis of SQSTM1 (arrow) using SQSTM1 Antibody . (SQSTM1 Antikörper (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SQSTM1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (SQSTM1 Antikörper (C-Term))

IHC (p)

Western blot analysis of SQSTM1 Antibody pre-incubated without (Lane 1) and with (Lane 2) blocking peptide in MCF-7 cell line lysate. (SQSTM1 Antikörper (C-Term))

Confocal immunofluorescent analysis of SQSTM1 Antibody with Hela cell followed by Alexa Fluor®488-conjugated Goat anti-Rabbit lgG (green). (SQSTM1 Antikörper (C-Term))

Immunofluorescence staining of Autophagy SQSTM1 Antibody on Methanol-fixed and PFA fixed HeLa cells. (SQSTM1 Antikörper (C-Term))

5 Abbildungen

Produktnummer ABIN1449619

Datenblatt (PDF)

Target Alle SQSTM1 Antikörper anzeigen

SQSTM1 (Sequestosome 1 (SQSTM1))
Bindungsspezifität
18

17

15

13

8

7

7

7

7

6

5

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 324-353, C-Term
Reaktivität
149

65

61

18

4

4

4

4

3

2

2

2

1

1

1

1
Human
Wirt
125

22

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
127

22
Polyklonal
Konjugat
70

11

10

7

7

6

4

4

4

4

4

4

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser SQSTM1 Antikörper ist unkonjugiert
Applikation
100

56

39

37

20

16

16

15

14

13

9

5

3

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung

Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen

KLH conjugated synthetic peptide between 324~353 amino acids from the C-terminal region of Human SQSTM1

Isotyp

Ig Fraction

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Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

0.25 mg/mL

Buffer

PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid repeated freezing and thawing.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target

SQSTM1 (Sequestosome 1 (SQSTM1))

Andere Bezeichnung

SQSTM1 (SQSTM1 Produkte)

Synonyme

SQSTM1 antikoerper, sqstm1 antikoerper, MGC79491 antikoerper, A170 antikoerper, OSIL antikoerper, PDB3 antikoerper, ZIP3 antikoerper, p60 antikoerper, p62 antikoerper, p62B antikoerper, OSF-6 antikoerper, Osi antikoerper, STAP antikoerper, ZIP antikoerper, sb:cb621 antikoerper, zgc:85784 antikoerper, sequestosome 1 antikoerper, sequestosome 1 L homeolog antikoerper, SQSTM1 antikoerper, sqstm1 antikoerper, Sqstm1 antikoerper, sqstm1.L antikoerper

Hintergrund

SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.Synonyms: EBI3-associated protein of 60 kDa, EBIAP, ORCA, OSIL, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Sequestosome-1, Ubiquitin-binding protein p62, p60, p62

Molekulargewicht

47687 Da

Gen-ID

8878

NCBI Accession

NP_001135770

Pathways

NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie