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SQSTM1 Antikörper (C-Term)

SQSTM1 Reaktivität: Human WB, IF, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1449619
  • Target Alle SQSTM1 Antikörper anzeigen
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Bindungsspezifität
    • 18
    • 17
    • 15
    • 13
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 324-353, C-Term
    Reaktivität
    • 149
    • 65
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 125
    • 22
    • 1
    • 1
    Kaninchen
    Klonalität
    • 127
    • 22
    Polyklonal
    Konjugat
    • 70
    • 11
    • 10
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SQSTM1 Antikörper ist unkonjugiert
    Applikation
    • 100
    • 56
    • 39
    • 37
    • 20
    • 16
    • 16
    • 15
    • 14
    • 13
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    KLH conjugated synthetic peptide between 324~353 amino acids from the C-terminal region of Human SQSTM1
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SQSTM1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Andere Bezeichnung
    SQSTM1 (SQSTM1 Produkte)
    Synonyme
    SQSTM1 antikoerper, sqstm1 antikoerper, MGC79491 antikoerper, A170 antikoerper, OSIL antikoerper, PDB3 antikoerper, ZIP3 antikoerper, p60 antikoerper, p62 antikoerper, p62B antikoerper, OSF-6 antikoerper, Osi antikoerper, STAP antikoerper, ZIP antikoerper, sb:cb621 antikoerper, zgc:85784 antikoerper, sequestosome 1 antikoerper, sequestosome 1 L homeolog antikoerper, SQSTM1 antikoerper, sqstm1 antikoerper, Sqstm1 antikoerper, sqstm1.L antikoerper
    Hintergrund
    SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.Synonyms: EBI3-associated protein of 60 kDa, EBIAP, ORCA, OSIL, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Sequestosome-1, Ubiquitin-binding protein p62, p60, p62
    Molekulargewicht
    47687 Da
    Gen-ID
    8878
    NCBI Accession
    NP_001135770
    Pathways
    NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie
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