zc3h9 antikoerper, gpatc6 antikoerper, gpatch6 antikoerper, zc3hdc9 antikoerper, GPATC6 antikoerper, GPATCH6 antikoerper, KIAA1847 antikoerper, ZC3H9 antikoerper, ZC3HDC9 antikoerper, ZIP antikoerper, 1500006I01Rik antikoerper, BC021513 antikoerper, RGD1310801 antikoerper, zgc:63730 antikoerper, zinc finger CCCH-type and G-patch domain containing antikoerper, zinc finger, CCCH-type with G-patch domain L homeolog antikoerper, zinc finger, CCCH-type with G-patch domain antikoerper, zinc finger, CCCH-type with G patch domain antikoerper, ZGPAT antikoerper, zgpat.L antikoerper, zgpat antikoerper, Zgpat antikoerper
Hintergrund
The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.Synonyms: G patch domain-containing protein 6, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, Zinc finger CCCH domain-containing protein 9, Zinc finger CCCH-type with G patch domain-containing protein