LY6K antikoerper, CT97 antikoerper, HSJ001348 antikoerper, ly-6K antikoerper, 2410015A16Rik antikoerper, 3110035B01Rik antikoerper, mLy-6K antikoerper, lymphocyte antigen 6 family member K antikoerper, lymphocyte antigen 6 complex, locus K antikoerper, LY6K antikoerper, Ly6k antikoerper
Hintergrund
The lymphocyte antigen 6 complex locus K (LY6K), a member of cancer-testis antigen was initially identified as a molecular marker for head-and-neck squamous cell carcinoma as well a breast cancer. LY6K is a GPI-anchored membrane protein that is specifically associated with germ cell marker TEX101 and is strongly observed in testis, but only weakly in other tissues. LY6K mRNA was found to be upregulated in numerous bladder cancers due to gene amplification. Furthermore, knockdown experiments using LY6K siRNA reduced cell growth, migration and invasion in bladder carcinoma cell lines, suggesting that LY6K contributes to bladder cancer development.Synonyms: CO16, Ly-6K, Lymphocyte antigen 6K