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CD63 Antikörper

CD63 Reaktivität: Maus FACS, WB Wirt: Ratte Monoclonal R5G2 unconjugated
Produktnummer ABIN1504148
  • Target Alle CD63 Antikörper anzeigen
    CD63
    Reaktivität
    • 130
    • 49
    • 9
    • 3
    • 2
    • 1
    Maus
    Wirt
    • 80
    • 60
    • 6
    • 2
    • 1
    Ratte
    Klonalität
    • 100
    • 47
    • 2
    Monoklonal
    Konjugat
    • 68
    • 12
    • 11
    • 9
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD63 Antikörper ist unkonjugiert
    Applikation
    • 93
    • 63
    • 51
    • 44
    • 37
    • 28
    • 26
    • 19
    • 17
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB)
    Spezifität
    This antibody reacts with mouse CD63.
    Aufreinigung
    Protein G agarose
    Klon
    R5G2
    Isotyp
    IgG2b
    Top Product
    Discover our top product CD63 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Konservierungsmittel
    Without preservative
  • Target
    CD63
    Andere Bezeichnung
    CD63 (CD63 Produkte)
    Synonyme
    C75951 antikoerper, ME491 antikoerper, Tspan30 antikoerper, LAMP-3 antikoerper, MLA1 antikoerper, OMA81H antikoerper, TSPAN30 antikoerper, TSP29FA antikoerper, CD63 antigen antikoerper, CD63 molecule antikoerper, Cd63 molecule antikoerper, Cd63 antikoerper, CD63 antikoerper
    Hintergrund
    CD63 is not only expressed on activated platelets, but also activated monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and translocated to cell surface upon various stimuli. The membrane of lytic granules in CTLs contains CD63/LAMP-3 and other lysosomal-associated glycoproteins (LAMPs) such as CD107a/LAMP-1 and CD107b/LAMP-2. LAMPs have b een observed on the cell surface as a result of degranulation. CD63 belongs to a member of the tetraspanin transmembrane-protein (TM4) superfamily, which includes CD9, CD37, CD53, CD81, CD82, CD151 and CD231. Several members of this family form noncovalent associations with integrins, particularly ß 1 integrins (CD29), and modulate cellular adhesion properties. CD63 has a tyrosine-based internalization motif in the cytoplasmic C-terminal tail and interacts with adaptor protein complexes such as AP-2 and AP-3. Because AP-2 and AP-3 are involved in facilitating the clathrin-mediated endocytosis, CD63 could be directly involved in the internalization of its membrane protein partners.Synonyms: Granulophysin, ME491, MLA1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, TSPAN30, Tetraspanin-30
    Gen-ID
    12512
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