70zpep antikoerper, PEP antikoerper, Ptpn8 antikoerper, LYP antikoerper, LYP1 antikoerper, LYP2 antikoerper, PTPN8 antikoerper, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antikoerper, protein tyrosine phosphatase, non-receptor type 22 antikoerper, Ptpn22 antikoerper, PTPN22 antikoerper
Hintergrund
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.,PTPN22,LYP,LYP1,LYP2,PEP,PTPN22.5,PTPN22.6,PTPN8,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PTPN22