This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.
DP(W3) antikoerper, DP(W4) antikoerper, HLA-DP1A antikoerper, HLADP antikoerper, HLASB antikoerper, PLT1 antikoerper, major histocompatibility complex, class II, DP alpha 1 antikoerper, HLA-DPA1 antikoerper
Hintergrund
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.