This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1.
Heab antikoerper, RGD1307679 antikoerper, AI462438 antikoerper, ACDP1 antikoerper, CLP-1 antikoerper, CGP-39 antikoerper, GP-39 antikoerper, SPC-40 antikoerper, SPS-40 antikoerper, YKL-40 antikoerper, HEAB antikoerper, hClp1 antikoerper, fa28a12 antikoerper, wu:fa28a12 antikoerper, clp1 antikoerper, cleavage and polyadenylation factor I subunit 1 antikoerper, CLP1, cleavage and polyadenylation factor I subunit antikoerper, cyclin and CBS domain divalent metal cation transport mediator 1 antikoerper, chitinase 3-like 1 (cartilage glycoprotein-39) antikoerper, cleavage and polyadenylation factor I subunit 1 L homeolog antikoerper, Clp1 antikoerper, CNNM1 antikoerper, CHI3L1 antikoerper, CLP1 antikoerper, clp1 antikoerper, clp1.L antikoerper
Hintergrund
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.