Macrophage Scavenger Receptor 1 Antikörper (C-Term)

Produktnummer ABIN1537159

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Target: Macrophage Scavenger Receptor 1 (MSR1)

Bindungsspezifität: AA 336-364, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.

Klon: RB36746

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: MSR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Referenzen für anti-Macrophage Scavenger Receptor 1 Antikörper (ABIN1537159)

Chen, Li, Zhu: "AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-?B/LOX-1 pathway." in: Vascular pharmacology, (2015) (PubMed).

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: MSR1 (MSR1 Produkte)

Synonyme: CD204 antikoerper, SCARA1 antikoerper, SR-A antikoerper, SRA antikoerper, phSR1 antikoerper, phSR2 antikoerper, MRS-A antikoerper, MSR antikoerper, MSR-A antikoerper, SR-AI antikoerper, SR-AII antikoerper, Scara1 antikoerper, Scvr antikoerper, MSR1 antikoerper, RGD1564316 antikoerper, macrophage scavenger receptor 1 antikoerper, scavenger receptor class A member 5 antikoerper, MSR1 antikoerper, Msr1 antikoerper, SCARA5 antikoerper

Hintergrund: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Molekulargewicht: 49762

Gen-ID: 4481

NCBI Accession: NP_002436, NP_619729, NP_619730

UniProt: P21757