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TNNT3 Antikörper (C-Term)

TNNT3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB36783 unconjugated
Produktnummer ABIN1537681
  • Target Alle TNNT3 Antikörper anzeigen
    TNNT3 (Fast Skeletal Troponin T (TNNT3))
    Bindungsspezifität
    • 11
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 217-245, C-Term
    Reaktivität
    • 40
    • 10
    • 9
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 28
    • 10
    • 2
    Kaninchen
    Klonalität
    • 32
    • 8
    Polyklonal
    Konjugat
    • 22
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNNT3 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 17
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This TNNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the C-terminal region of human TNNT3.
    Klon
    RB36783
    Isotyp
    Ig Fraction
    Top Product
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  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    TNNT3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    TNNT3 (Fast Skeletal Troponin T (TNNT3))
    Andere Bezeichnung
    TNNT3 (TNNT3 Produkte)
    Synonyme
    fTnT antikoerper, tnnt3a antikoerper, TNTF antikoerper, TnTf antikoerper, Tnt antikoerper, Tnnt3 antikoerper, troponin T3, fast skeletal type antikoerper, troponin T3, skeletal, fast antikoerper, troponin T3, fast skeletal type S homeolog antikoerper, troponin T type 3 (skeletal, fast) antikoerper, troponin T1, slow skeletal type antikoerper, TNNT3 antikoerper, Tnnt3 antikoerper, tnnt3.S antikoerper, TNNT1 antikoerper
    Hintergrund
    The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).
    Molekulargewicht
    31825
    Gen-ID
    7140
    NCBI Accession
    NP_001036245, NP_001036246, NP_001036247, NP_006748
    UniProt
    P45378
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