Otopetrin 2 Antikörper (AA 336-363)

Produktnummer ABIN1538326

Produktdetails anti-Otopetrin 2 Antikörper

Target: Otopetrin 2 (OTOP2)

Bindungsspezifität: AA 336-363

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Otopetrin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This OTOP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the Central region of human OTOP2.

Klon: RB37737

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: OTOP2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Otopetrin 2

Target: Otopetrin 2 (OTOP2)

Andere Bezeichnung: OTOP2 (OTOP2 Produkte)

Synonyme: OTOP2 antikoerper, 4732464P15 antikoerper, otopetrin 2 antikoerper, OTOP2 antikoerper, otop2 antikoerper, Otop2 antikoerper

Hintergrund: Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.

Molekulargewicht: 62236

Gen-ID: 92736

NCBI Accession: NP_835454

UniProt: Q7RTS6