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Shugoshin Antikörper (AA 339-367)

SGOL1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB36785 unconjugated
Produktnummer ABIN1538328
  • Target Alle Shugoshin (SGOL1) Antikörper anzeigen
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Bindungsspezifität
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 339-367
    Reaktivität
    • 44
    • 5
    • 5
    • 1
    • 1
    Human
    Wirt
    • 42
    • 3
    Kaninchen
    Klonalität
    • 43
    • 2
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Shugoshin Antikörper ist unkonjugiert
    Applikation
    • 30
    • 27
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SGOL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human SGOL1.
    Klon
    RB36785
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SGOL1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    SGOL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Andere Bezeichnung
    SGOL1 (SGOL1 Produkte)
    Synonyme
    sgo1 antikoerper, NY-BR-85 antikoerper, SGO antikoerper, Sgo1 antikoerper, 3300001M08Rik antikoerper, C81037 antikoerper, shugoshin 1 antikoerper, shugoshin centromeric cohesion 1 antikoerper, shugoshin 1 L homeolog antikoerper, Sgo1 antikoerper, sgo1 antikoerper, sgo1.L antikoerper, SGO1 antikoerper
    Hintergrund
    SGOL1 plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
    Molekulargewicht
    64190
    Gen-ID
    151648
    NCBI Accession
    NP_001012409, NP_001012410, NP_001012411, NP_001012412, NP_001012413, NP_001186180, NP_001186181, NP_001186182, NP_001186183, NP_001186184, NP_001186185, NP_001186186, NP_612493
    UniProt
    Q5FBB7
    Pathways
    Maintenance of Protein Location
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