This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SH3BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-446 amino acids from the Central region of human SH3BP1.
ARHGAP43 antikoerper, 3BP-1 antikoerper, SH3BP1 antikoerper, SH3 domain binding protein 1 antikoerper, SH3-domain binding protein 1 antikoerper, SH3 domain-binding protein 1 antikoerper, SH3BP1 antikoerper, Sh3bp1 antikoerper, LOC100398528 antikoerper
Hintergrund
SH3BP1 binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho-or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).