This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ARHGEF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-632 amino acids from the Central region of human ARHGEF11.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.