This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This MPZL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human MPZL2.
cb837 antikoerper, eva1 antikoerper, mpzl2 antikoerper, wu:fb07b02 antikoerper, EVA1 antikoerper, EVA antikoerper, Eva antikoerper, Eva1 antikoerper, myelin protein zero-like 2b antikoerper, myelin protein zero like 2 antikoerper, myelin protein zero-like 2 antikoerper, mpzl2b antikoerper, MPZL2 antikoerper, Mpzl2 antikoerper
Hintergrund
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain, a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].