This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PPFIA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human PPFIA1.
LIP.1 antikoerper, LIP1 antikoerper, LIPRIN antikoerper, C030014K08Rik antikoerper, C87158 antikoerper, PTPRF interacting protein alpha 1 antikoerper, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 antikoerper, PPFIA1 antikoerper, Ppfia1 antikoerper
Hintergrund
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.