DBN1 Antikörper (AA 1-326)

Produktnummer ABIN1558079

Produktdetails anti-DBN1 Antikörper

Target: DBN1 (Drebrin 1 (DBN1))

Bindungsspezifität: AA 1-326

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DBN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Spezifität: The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Klon: DBN-N-03

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western blotting: Positive control: REH, Nalm-6, HEK293 cells.
Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Andere Bezeichnung: Drebrin (DBN1 Produkte)

Synonyme: D0S117E antikoerper, DBN1 antikoerper, LOC733967 antikoerper, drebrin 1 antikoerper, drebrin 1 S homeolog antikoerper, DBN1 antikoerper, Dbn1 antikoerper, dbn1.S antikoerper, dbn1 antikoerper

Hintergrund: Drebrin 1,Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.,DBN, D0S117E

Gen-ID: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location