HSP27 Antikörper

Produktnummer ABIN1580426

Produktdetails anti-HSP27 Antikörper

Target: HSP27 (Heat Shock Protein 27 (HSP27))

Reaktivität: Human, Rind (Kuh), Maus, Schwein, Ratte, Säugetier

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSP27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Aufreinigung: affinity purified antibody

Klon: 6H11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: The antibody solution can be used at dilutions of at least 1:1,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:10,000 or lower.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4°C short term or -20°C long term.

Details zu HSP27

Target: HSP27 (Heat Shock Protein 27 (HSP27))

Andere Bezeichnung: Heat shock protein 27- HSP27 (HSP27 Produkte)

Synonyme: 27 antikoerper, 27K antikoerper, 28 antikoerper, CG4466 antikoerper, Dhsp27 antikoerper, DmHSP27 antikoerper, DmHsp27 antikoerper, Dmel\\CG4466 antikoerper, HSP27 antikoerper, HSP28 antikoerper, Hsp 27 antikoerper, Hsp28 antikoerper, anon-WO0140519.69 antikoerper, hsp 27 antikoerper, hsp-27 antikoerper, hsp26 antikoerper, hsp27 antikoerper, hsp27/26 antikoerper, hsp28 antikoerper, small hsp locus 67B antikoerper, Heat shock protein 27 antikoerper, heat shock protein 27 antikoerper, Hsp27 antikoerper, CpipJ_CPIJ005642 antikoerper

Hintergrund: The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1). The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP27 has an apparent molecular weight of 27 kDa. It is an abundant protein even under non-stress conditions and frequently shows up as a major spot on 2 dimensional gels of cells or tissues. It is known to associate with a variety of other proteins such as actin, intermediate filament subunits and ubiquitin and is found both in the cytoplasm and the nucleus of cells. HSP27 can become heavily phosphorylated under the influence of multiple protein kinases particularly as a result of activation of the p38/SAPK pathway. Upregulation of this protein is protective against neurodegenerative diseases at least in certain mouse models. Point mutations in the HSP27 gene are associated with two neurological diseases, Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy IIB. These diseases are associated with axonal loss apparently following defects in the transport of neurofilaments. The HGNC name for this protein is HSBP1.

Pathways: VEGF Signaling