VEGFC Antikörper

Produktnummer ABIN1589911

Produktdetails anti-VEGFC Antikörper

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: VEGF-C antibody

Spezifität: Recombinant rat VEGF-C

Produktmerkmale: Chromosomal location: 16p11
Produced from sera of rabbits immunized with highly pure recombinant rat dNdC-VEGF-C.

Aufreinigung: Anti-rat VEGF-C IgG was purified by affinity chromatography with immobilized Protein A.

Immunogen: Recombinant rat VEGF-C (ABIN1589785)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Use 2-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handhabung: Centrifuge vial prior to opening.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Haltbarkeit: 24 months

Referenzen für anti-VEGFC Antikörper (ABIN1589911)

Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: "Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis." in: PLoS ONE, Vol. 9, Issue 9, pp. e106976, (2014) (PubMed).

Details zu VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Andere Bezeichnung: VEGF-C (VEGFC Produkte)

Synonyme: VEGFC antikoerper, vegf-c antikoerper, xvegf-c antikoerper, Flt4-L antikoerper, VRP antikoerper, AW228853 antikoerper, VEGF-C antikoerper, vascular endothelial growth factor c antikoerper, vascular endothelial growth factor C antikoerper, vascular endothelial growth factor C S homeolog antikoerper, vegfc antikoerper, VEGFC antikoerper, vegfc.S antikoerper, Vegfc antikoerper

Hintergrund: Vascular endothelial growth factor C, Vegfc,VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

Gen-ID: 114111

NCBI Accession: NM_053653, NP_446105

UniProt: O35757

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2