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Myosin VI Antikörper

Rockland 100-401-j03 MYO6 Reaktivität: Human, Schwein WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Rockland
Produktnummer ABIN1607600
Hersteller Produkt- Nr.: 100-401-j03
  • Target Alle Myosin VI (MYO6) Antikörper anzeigen
    Myosin VI (MYO6)
    Reaktivität
    • 19
    • 19
    • 18
    • 1
    • 1
    Human, Schwein
    Wirt
    • 32
    • 1
    Kaninchen
    Klonalität
    • 32
    • 1
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Myosin VI Antikörper ist unkonjugiert
    Applikation
    • 18
    • 15
    • 13
    • 13
    • 13
    • 8
    • 8
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Hersteller Produkt- Nr.
    100-401-j03
    Hersteller
    Rockland
    Verwendungszweck
    Myosin-6 Antibody
    Kreuzreaktivität (Details)
    Anti-Myosin-6 is directed against the myosin-6 protein.
    Produktmerkmale
    Synonyms: rabbit anti-Myosin-6 Antibody, MyosinVI, Unconventional myosin 6
    Aufreinigung
    The product was prepared from monospecific antiserum by delipidation and defibrination.
    Sterilität
    Sterile filtered
    Immunogen

    Immunogen: Anti-Myosin-6 was prepared from whole rabbit serum produced by repeated immunizations with full length myosin-6 construct expressed in SF9 insect cells corresponding to porcine myosyn-6 protein.

    Immunogen Type: Recombinant Protein

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  • Applikationshinweise

    Application Note: Myosin-6 antibody has been tested by western blot. For western blots expect a band of approximately 150 kDa in size corresponding to full length and ~85 kDa and ~60 kDa for truncated myosin-6 protein. Specific conditions for reactivity should be optimized by the end user. This antibody is suitable for use in ELISA.

    Western Blot Dilution: 1:1000

    ELISA Dilution: 1:10,000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    25 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Target
    Myosin VI (MYO6)
    Andere Bezeichnung
    MYO6 (MYO6 Produkte)
    Hintergrund
    Background: Myosin VI is a myosin superfamily member with unique and intriguing features that allow it to fill a still-expanding number of cell biological roles. This actin-based motor produces force that acts towards the minus end of actin filaments, which is the opposite direction to all other characterized myosins. In mammalian cells, myosin VI is localized to endocytic vesicles, membrane ruffles, the cytosol and the Golgi complex. Its motor function is essential for several physiological functions of the cell, including normal rates of endocytosis, maintenance of Golgi morphology and protein secretion. Myosin VI regulates epithelial cell migration and plays a role in the maintenance of adhesive cellular contacts within epithelial cell layers. It is highly expressed in ovarian cancers and prostate cancers and its expression level, which is upregulated by DNA damage in a p53-dependent manner, correlates with the potential of the tumor to disseminate. More recently, myosin VI has been found involved in EGFR endocytosis through a clathrin dependent mechanism.
    Gen-ID
    397085
    NCBI Accession
    NP_999186
    UniProt
    Q29122
    Pathways
    Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization
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