BIN1 Antikörper (AA 230-409)

Produktnummer ABIN1678863

Produktdetails anti-BIN1 Antikörper

Target: BIN1 (Bridging Integrator 1 (BIN1))

Bindungsspezifität: AA 230-409

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQSSLPAV VVETFPATVN GTVEGGSGAG RLDLPPGFMF KVQAQHDYTA TDTDELQLKA GDVVLVIPFQ NPEEQDEGWL MGVKESDWNQ HKELEKCRGV FPENFTERVP

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:20 - 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu BIN1

Target: BIN1 (Bridging Integrator 1 (BIN1))

Andere Bezeichnung: BIN1 (BIN1 Produkte)

Synonyme: bin1 antikoerper, MGC53185 antikoerper, amph2 antikoerper, amphl antikoerper, sh3p9 antikoerper, MGC76187 antikoerper, cb57 antikoerper, zgc:86701 antikoerper, BIN1 antikoerper, AMPH2 antikoerper, AMPHL antikoerper, SH3P9 antikoerper, ALP-1 antikoerper, Amphl antikoerper, BRAMP-2 antikoerper, bridging integrator 1 antikoerper, bridging integrator 1 S homeolog antikoerper, bridging integrator 1b antikoerper, BIN1 antikoerper, bin1.S antikoerper, bin1 antikoerper, bin1b antikoerper, Bin1 antikoerper

Hintergrund: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.,BIN1,AMPH2,AMPHL,SH3P9,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,BIN1

Molekulargewicht: 45-64 kDa

Gen-ID: 274

UniProt: O00499