CASR Antikörper (AA 874-1088)

Produktnummer ABIN1678994

Produktdetails anti-CASR Antikörper

Target: CASR (Calcium-Sensing Receptor (CASR))

Bindungsspezifität: AA 874-1088

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PSRNTIEEVR CSTAAHAFKV AARATLRRSN VSRKRSSSLG GSTGSTPSSS ISSKSNSEDP FPQPERQKQQ QPLALTQQEQ QQQPLTLPQQ QRSQQQPRCK QKVIFGSGTV TFSLSFDEPQ KNAMAHRNST HQNSLEAQKS SDTLTRHQPL LPLQCGETDL DLTVQETGLQ GPVGGDQRPE VEDPEELSPA LVVSSSQSFV ISGGGSTVTE NVVNS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 874-1088 of human CASR (NP_001171536.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-CASR Antikörper (ABIN1678994)

Xiao, Su, Feng, Sun, Liu, Zhang, Lu, Li, Wang, Zhu, Hu: "Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor." in: Journal of the American Heart Association, Vol. 6, Issue 4, (2017) (PubMed).

Details zu CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Andere Bezeichnung: CASR (CASR Produkte)

Synonyme: CAR antikoerper, EIG8 antikoerper, FHH antikoerper, FIH antikoerper, GPRC2A antikoerper, HHC antikoerper, HHC1 antikoerper, HYPOC1 antikoerper, NSHPT antikoerper, PCAR1 antikoerper, CaR antikoerper, Gprc2a antikoerper, gprc2a antikoerper, xV2R F-1 antikoerper, CASR antikoerper, calcium sensing receptor antikoerper, calcium-sensing receptor antikoerper, calcium-sensing receptor L homeolog antikoerper, CASR antikoerper, Casr antikoerper, casr.L antikoerper

Hintergrund: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.,CASR,CAR,EIG8,FHH,FIH,GPRC2A,HHC,HHC1,HYPOC1,NSHPT,PCAR1,hCasR,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,Growth factor,Endocrine & Metabolism,Neuroscience,Calcium Signaling,CASR

Molekulargewicht: 120 kDa/121 kDa

Gen-ID: 846

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis