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EIF3A Antikörper (AA 1-250)

EIF3A Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1679692
  • Target Alle EIF3A Antikörper anzeigen
    EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
    Bindungsspezifität
    • 10
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-250
    Reaktivität
    • 41
    • 19
    • 14
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 39
    • 3
    Kaninchen
    Klonalität
    • 40
    • 2
    Polyklonal
    Konjugat
    • 21
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EIF3A Antikörper ist unkonjugiert
    Applikation
    • 30
    • 20
    • 19
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequenz
    MPAYFQRPEN ALKRANEFLE VGKKQPALDV LYDVMKSKKH RTWQKIHEPI MLKYLELCVD LRKSHLAKEG LYQYKNICQQ VNIKSLEDVV RAYLKMAEEK TEAAKEESQQ MVLDIEDLDN IQTPESVLLS AVSGEDTQDR TDRLLLTPWV KFLWESYRQC LDLLRNNSRV ERLYHDIAQQ AFKFCLQYTR KAEFRKLCDN LRMHLSQIQR HHNQSTAINL NNPESQSMHL ETRLVQLDSA ISMELWQEAF
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human EIF3A (NP_003741.1).
    Isotyp
    IgG
    Top Product
    Discover our top product EIF3A Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:1000,IF,1:50 - 1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Yang, Hu, Fan, Zhang, Zhong, Guo, Qin, Chen: "Picornavirus 2A protease regulates stress granule formation to facilitate viral translation." in: PLoS pathogens, Vol. 14, Issue 2, pp. e1006901, (2018) (PubMed).

  • Target
    EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))
    Andere Bezeichnung
    EIF3A (EIF3A Produkte)
    Synonyme
    EIF3 antikoerper, EIF3S10 antikoerper, P167 antikoerper, TIF32 antikoerper, eIF3-p170 antikoerper, eIF3-theta antikoerper, p180 antikoerper, p185 antikoerper, EIF6 antikoerper, A830012B05Rik antikoerper, Csma antikoerper, Eif3 antikoerper, Eif3s10 antikoerper, mKIAA0139 antikoerper, ZH12 antikoerper, eif3s10 antikoerper, eIF3 p110 antikoerper, eIF3a antikoerper, eukaryotic translation initiation factor 3 subunit A antikoerper, eukaryotic translation initiation factor 3, subunit A antikoerper, eukaryotic translation initiation factor 3 subunit A S homeolog antikoerper, translation initiation factor eIF3a antikoerper, EIF3A antikoerper, Eif3a antikoerper, eif3a.S antikoerper, tif32 antikoerper
    Hintergrund
    RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).,EIF3A,EIF3,EIF3S10,P167,TIF32,eIF3-p170,eIF3-theta,p180,p185,Epigenetics & Nuclear Signaling,RNA Binding,Translation Control,EIF3A
    Molekulargewicht
    162 kDa/166 kDa
    Gen-ID
    8661
    UniProt
    Q14152
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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