SERPINH1 Antikörper

Produktnummer ABIN1686616

Produktdetails anti-SERPINH1 Antikörper

Target: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SERPINH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Detects 47 kDa.

Kreuzreaktivität: Human

Aufreinigung: Protein G Purified

Immunogen: Human HSP47, full length

Klon: 1C4-1A6

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN1686616 was sufficient for detection of HSP47 in 20 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu SERPINH1

Target: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Andere Bezeichnung: HSP47 (SERPINH1 Produkte)

Synonyme: AsTP3 antikoerper, CBP1 antikoerper, CBP2 antikoerper, HSP47 antikoerper, OI10 antikoerper, PPROM antikoerper, RA-A47 antikoerper, SERPINH2 antikoerper, gp46 antikoerper, SERPINH1 antikoerper, DKFZp468B197 antikoerper, cb216 antikoerper, hsp antikoerper, hsp47 antikoerper, id:ibd5060 antikoerper, wu:fc56b02 antikoerper, BERF-1 antikoerper, Cbp1 antikoerper, Cbp2 antikoerper, Hsp47 antikoerper, J6 antikoerper, Serpinh2 antikoerper, colligin antikoerper, astp3 antikoerper, cbp1 antikoerper, cbp2 antikoerper, pig14 antikoerper, pprom antikoerper, ra-a47 antikoerper, serpinh2 antikoerper, serpin family H member 1 antikoerper, serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b antikoerper, serpin H1 antikoerper, selenoprotein K antikoerper, serine (or cysteine) peptidase inhibitor, clade H, member 1 antikoerper, serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) L homeolog antikoerper, SERPINH1 antikoerper, serpinh1b antikoerper, LOC100009353 antikoerper, Selenok antikoerper, Serpinh1 antikoerper, serpinh1.L antikoerper

Hintergrund: HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1). The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).

Gen-ID: 871

NCBI Accession: NP_001193943

UniProt: P50454