LAIR1 Antikörper (PE)

Produktnummer ABIN1690739

Produktdetails anti-LAIR1 Antikörper (PE)

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAIR1 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: The mouse monoclonal antibody NKTA255 recognizes an extracellular epitope of CD305 / LAIR1, a 40 kDa type I transmembrane glycoprotein expressed on NK, T, and B cells, monocytes, dendritic cells, eosinophils, basophils, mast cells, CD34+ hematopoietic progenitor cells and thymocytes.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Activated NK cells and CD3- thymocytes

Klon: NKTA255

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Kommentare:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-LAIR1 Antikörper (PE) (ABIN1690739)

Colombo, Canevali, Magnani, Rossi, Puppo, Zocchi, Poggi: "Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients." in: PLoS ONE, Vol. 7, Issue 2, pp. e31903, (2012) (PubMed).

Son, Santiago-Schwarz, Al-Abed, Diamond: "C1q limits dendritic cell differentiation and activation by engaging LAIR-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 46, pp. E3160-7, (2012) (PubMed).

Meyaard: "The inhibitory collagen receptor LAIR-1 (CD305)." in: Journal of leukocyte biology, Vol. 83, Issue 4, pp. 799-803, (2008) (PubMed).

Warren: "The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section report." in: Cellular immunology, Vol. 236, Issue 1-2, pp. 17-20, (2005) (PubMed).

Poggi, Tomasello, Ferrero, Zocchi, Moretta: "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor." in: European journal of immunology, Vol. 28, Issue 7, pp. 2086-91, (1998) (PubMed).

Poggi, Tomasello, Revello, Nanni, Costa, Moretta: "p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes." in: International immunology, Vol. 9, Issue 9, pp. 1271-9, (1997) (PubMed).

Details zu LAIR1

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Andere Bezeichnung: CD305 / LAIR1 (LAIR1 Produkte)

Synonyme: 5133400O11Rik antikoerper, BB115266 antikoerper, D7Bwg0421e antikoerper, Lair-1 antikoerper, mLair-1 antikoerper, CD305 antikoerper, LAIR-1 antikoerper, leukocyte-associated Ig-like receptor 1 antikoerper, leukocyte associated immunoglobulin like receptor 1 antikoerper, leukocyte-associated immunoglobulin-like receptor 1 antikoerper, Lair1 antikoerper, LAIR1 antikoerper

Hintergrund: Leukocyte associated immunoglobulin like receptor,CD305, also known as LAIR1 (leukocyte-associated Ig-like receptor 1), is an inhibitory receptor found on many types of peripheral blood cells. It serves to suppress cell cytotoxicity, activation, proliferation, and differentiation regarding autoantigens via its two intracellular ITIM sites. CD305 belongs to the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family of proteins. It reacts with collagen ligands.,LAIR1

Gen-ID: 3903

UniProt: Q6GTX8