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GAS2 Antikörper (AA 141-240) (AbBy Fluor® 350)

GAS2 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1693036
  • Target Alle GAS2 Antikörper anzeigen
    GAS2 (Growth Arrest-Specific 2 (GAS2))
    Bindungsspezifität
    • 14
    • 14
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 141-240
    Reaktivität
    • 56
    • 15
    • 10
    Human
    Wirt
    • 51
    • 5
    Kaninchen
    Klonalität
    • 54
    • 2
    Polyklonal
    Konjugat
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GAS2 Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 29
    • 26
    • 12
    • 12
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GAS2
    Isotyp
    IgG
    Top Product
    Discover our top product GAS2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GAS2 (Growth Arrest-Specific 2 (GAS2))
    Andere Bezeichnung
    GAS2 (GAS2 Produkte)
    Synonyme
    GAS2 antikoerper, gas2 antikoerper, si:packt119.1 antikoerper, GAS-2 antikoerper, Gas-2 antikoerper, RGD1563167 antikoerper, growth arrest specific 2 antikoerper, growth arrest-specific 2b antikoerper, growth arrest-specific 2 antikoerper, GAS2 antikoerper, gas2b antikoerper, Gas2 antikoerper
    Hintergrund

    Synonyms: GAS 2, GAS-2, Gas2, GAS2_HUMAN, Growth arrest specic 2, Growth arrest specic protein 2, Growth arrest-specic protein 2, MGC32610.

    Background: Gas2 is a 313 amino acid protein encoded by the human gene GAS2. Gas2 is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 and caspase-7) at Asparagine 278 during apoptosis. The cleaved form resulting from this dramatically induces the rearrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is believed to also be involved in the membrane ruffling process. During the G0-G1 transition phase Gas2 can be found phosphorylated on its serine residues. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated but when hyperphosphorylated it will accumulate at membrane ruffles. Gas2 is specifically expressed at growth arrest and is ubiquitously expressed with highest levels found in liver, lung and kidney. There is no evidence, however, of Gas2 expression in spleen.

    Gen-ID
    2620
    Pathways
    Caspase Kaskade in der Apoptose
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