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DMC1 Antikörper (AA 251-340) (AbBy Fluor® 350)

DMC1 Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1693532
  • Target Alle DMC1 Antikörper anzeigen
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Bindungsspezifität
    • 15
    • 14
    • 9
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-340
    Reaktivität
    • 56
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 48
    • 8
    Kaninchen
    Klonalität
    • 49
    • 7
    Polyklonal
    Konjugat
    • 29
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DMC1 Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 49
    • 29
    • 21
    • 14
    • 12
    • 12
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DMC1
    Isotyp
    IgG
    Top Product
    Discover our top product DMC1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DMC1 (DNA Meiotic Recombinase 1 (DMC1))
    Andere Bezeichnung
    Dmc1 (DMC1 Produkte)
    Synonyme
    DMC1 antikoerper, zgc:136628 antikoerper, Dmc1h antikoerper, Lim15 antikoerper, Mei11 antikoerper, sgdp antikoerper, DCM1 antikoerper, DMC1H antikoerper, LIM15 antikoerper, dJ199H16.1 antikoerper, DNA meiotic recombinase 1 antikoerper, DMC1 antikoerper, dmc1 antikoerper, Dmc1 antikoerper
    Hintergrund

    Synonyms: disrupted meiotic cDNA 1 homolog, dJ199H16.1, DMC 1, DMC1 dosage suppressor of mck1 homolog, DMC1 dosage suppressor of mck1 homolog meiosis specic homologous recombination yeast, DMC1 homologue, DMC1H, HsLim15, LIM15, Meiotic recombination protein DMC1/LIM15 homolog, MGC150472, MGC150473, DMC1_HUMAN.

    Background: DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.

    Gen-ID
    11144
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