SIX2 Antikörper (AA 101-200) (AbBy Fluor® 350)

Produktnummer ABIN1693802

Produktdetails anti-SIX2 Antikörper (AbBy Fluor® 350)

Target: SIX2 (SIX Homeobox 2 (SIX2))

Bindungsspezifität: AA 101-200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIX2 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SIX2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SIX2

Target: SIX2 (SIX Homeobox 2 (SIX2))

Andere Bezeichnung: SIX2 (SIX2 Produkte)

Synonyme: six2-A antikoerper, zgc:195089 antikoerper, zgc:195096 antikoerper, six2.1 antikoerper, wu:fj04e08 antikoerper, zgc:91945 antikoerper, SIX homeobox 2 antikoerper, sine oculis-related homeobox 2 antikoerper, SIX homeobox 2 S homeolog antikoerper, SIX homeobox 2b antikoerper, SIX homeobox 2a antikoerper, SIX2 antikoerper, Six2 antikoerper, six2.S antikoerper, six2b antikoerper, six2a antikoerper

Hintergrund:

Synonyms: Homeobox protein SIX2, OTTHUMP00000201649, Sine oculis homeobox Drosophila homolog 2, Sine oculis homeobox homolog 2, Sine oculis homeobox homolog 2 Drosophila, SIX homeobox 2, Six2, SIX2_HUMAN.

Background: The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues.

Gen-ID: 10736

Pathways: Protein targeting to Nucleus