C4B Antikörper (AA 1454-1550) (AbBy Fluor® 488)

Produktnummer ABIN1694516

Produktdetails anti-C4B Antikörper (AbBy Fluor® 488)

Target: C4B (C4b) (Complement Component C4b (C4b))

Bindungsspezifität: AA 1454-1550

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4B Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement C4 gamma chain

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu C4B

Target: C4B (C4b) (Complement Component C4b (C4b))

Andere Bezeichnung: Complement C4 gamma chain (C4b Produkte)

Synonyme: C4B1 antikoerper, C4B12 antikoerper, C4B2 antikoerper, C4B3 antikoerper, C4B5 antikoerper, C4BD antikoerper, C4B_2 antikoerper, C4F antikoerper, CH antikoerper, CO4 antikoerper, CPAMD3 antikoerper, C4 antikoerper, C4A2 antikoerper, C4A3 antikoerper, C4A4 antikoerper, C4A6 antikoerper, C4AD antikoerper, C4S antikoerper, CPAMD2 antikoerper, RG antikoerper, wu:fi14a03 antikoerper, C4B antikoerper, DKFZP469I0332 antikoerper, Slp antikoerper, Ss antikoerper, C4-2 antikoerper, C4l antikoerper, complement C4B (Chido blood group) antikoerper, complement C4A (Rodgers blood group) antikoerper, complement component 4 antikoerper, complement C4-B antikoerper, complement component 4B (Chido blood group) antikoerper, complement component 4A (Rodgers blood group) antikoerper, C4B antikoerper, C4A antikoerper, c4 antikoerper, LOC462577 antikoerper, C4a antikoerper, C4b antikoerper

Hintergrund:

Synonyms: C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2, CH, C4F, C4B1, C4B2, C4B3, C4B5, C4BD, C4B12, C4B_2, CPAMD3, Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A

Background: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Gen-ID: 720721

UniProt: P0C0L4

Pathways: Komplementsystem