AFAP1L2 Antikörper (AbBy Fluor® 488)

Produktnummer ABIN1694742

Produktdetails anti-AFAP1L2 Antikörper (AbBy Fluor® 488)

Target: AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFAP1L2 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Homologie: Human,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AFAP1L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu AFAP1L2

Target: AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))

Andere Bezeichnung: Afap1l2 (AFAP1L2 Produkte)

Synonyme: KIAA1914 antikoerper, XB130 antikoerper, AU041783 antikoerper, C86904 antikoerper, mKIAA1914 antikoerper, RGD1310668 antikoerper, actin filament associated protein 1 like 2 antikoerper, actin filament associated protein 1-like 2 antikoerper, AFAP1L2 antikoerper, Afap1l2 antikoerper

Hintergrund:

Synonyms: KIAA1914, XB130, Actin filament-associated protein 1-like 2, AF1L2_HUMAN, AFAP1-like protein 2, afap1l2.

Background: Actin filament associated protein (AFAP-110) interacts directly with actin filaments through its C-terminal actin-binding domain. AFAP-110 contains additional protein-binding domains as well, and serves as an adaptor protein. By linking signaling molecules to actin filaments, AFAP-110 provides a platform for the preparation of larger signaling complexes, activates Src kinases in response to cellular signals and also directly affects Actin organization as an Actin filament cross-linking protein. AFAP-1L2 (Actin filament-associated protein 1-like 2), also known as XB130, is a 818 amino acid cytoplasmic protein that contains two Pleckstrin homology (PH) domains, which are normally found in proteins involved in intracellular signaling. Like its relative AFAP110, AFAP-1L2 interacts with Src kinase and may play a role in Src-regulated transcription activation. AFAP-1L2 is expressed in thyroid and spleen and can also be detected at lower levels in lung, brain, pancreas and kidney. There are four isoforms of AFAP-1L2 that are produced as a result of alternative splicing events.

Pathways: EGFR Signaling Pathway