POLI Antikörper (AA 51-150) (AbBy Fluor® 488)
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- Target Alle POLI Antikörper anzeigen
- POLI (Polymerase (DNA Directed) iota (POLI))
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Bindungsspezifität
- AA 51-150
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser POLI Antikörper ist konjugiert mit AbBy Fluor® 488
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DNA Polymerase iota
- Isotyp
- IgG
- Top Product
- Discover our top product POLI Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- POLI (Polymerase (DNA Directed) iota (POLI))
- Andere Bezeichnung
- DNA Polymerase iota (POLI Produkte)
- Synonyme
- poli antikoerper, wu:fc27h11 antikoerper, zgc:110185 antikoerper, GB12093 antikoerper, NV16187 antikoerper, RAD30B antikoerper, RAD3OB antikoerper, Rad30b antikoerper, DNA polymerase iota antikoerper, polymerase (DNA directed) iota antikoerper, polymerase (DNA directed), iota antikoerper, POLI antikoerper, poli antikoerper, LOC551219 antikoerper, AFUA_4G11140 antikoerper, LOC5568276 antikoerper, Pol-iota antikoerper, Poli antikoerper
- Hintergrund
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Synonyms: DNA polymerase iota, Eta 2, Eta2, POLI, POLI_HUMAN, Polymerase DNA directed iota, RAD 30B, RAD30 homolog B, RAD30B, RAD3OB.
Background: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol , which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
- Gen-ID
- 11201
- Pathways
- DNA Reparatur
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