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GLDC Antikörper (AA 51-150) (AbBy Fluor® 488)

GLDC Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 488
Produktnummer ABIN1695510
  • Target Alle GLDC Antikörper anzeigen
    GLDC (Glycine Dehydrogenase (GLDC))
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 46
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 47
    Kaninchen
    Klonalität
    • 47
    Polyklonal
    Konjugat
    • 18
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GLDC Antikörper ist konjugiert mit AbBy Fluor® 488
    Applikation
    • 43
    • 19
    • 12
    • 12
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GLDC
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GLDC (Glycine Dehydrogenase (GLDC))
    Andere Bezeichnung
    GLDC (GLDC Produkte)
    Synonyme
    PSPTO1276 antikoerper, Tb07.43M14.350 antikoerper, DDBDRAFT_0219205 antikoerper, DDBDRAFT_0231130 antikoerper, DDB_0219205 antikoerper, DDB_0231130 antikoerper, D030049L12Rik antikoerper, D19Wsu57e antikoerper, GCE antikoerper, GCSP antikoerper, HYGN1 antikoerper, fb23b05 antikoerper, wu:fb23b05 antikoerper, zgc:66198 antikoerper, gldc antikoerper, glycine dehydrogenase (decarboxylating) GcvP antikoerper, glycine dehydrogenase antikoerper, glycine cleavage system P-protein antikoerper, glycine decarboxylase antikoerper, glycine dehydrogenase (decarboxylating) antikoerper, glycine decarboxylase S homeolog antikoerper, gcvP antikoerper, Tb927.7.1910 antikoerper, Gldc antikoerper, GLDC antikoerper, gldc antikoerper, gldc.S antikoerper
    Hintergrund

    Synonyms: GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase decarboxylating mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase decarboxylating, HYGN1, MGC138198, MGC138200, NKH.

    Background: The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

    Gen-ID
    2731
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