HHATL Antikörper (AA 25-125) (AbBy Fluor® 488)

Produktnummer ABIN1695886

Produktdetails anti-HHATL Antikörper (AbBy Fluor® 488)

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Bindungsspezifität: AA 25-125

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HHATL Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HHATL/GUP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HHATL

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Andere Bezeichnung: HHATL/GUP1 (HHATL Produkte)

Synonyme: Gup1 antikoerper, RGD1311911 antikoerper, gup1 antikoerper, oact3 antikoerper, mboat3 antikoerper, MGC53261 antikoerper, mstp002 antikoerper, MGC89797 antikoerper, GUP1 antikoerper, 1110011D13Rik antikoerper, C3orf3 antikoerper, MBOAT3 antikoerper, MSTP002 antikoerper, OACT3 antikoerper, c3orf3b antikoerper, gup1b antikoerper, im:7145545 antikoerper, wu:fc04e05 antikoerper, zgc:154131 antikoerper, c3orf3a antikoerper, gup1a antikoerper, zgc:77750 antikoerper, hedgehog acyltransferase-like antikoerper, hedgehog acyltransferase like S homeolog antikoerper, hedgehog acyltransferase like antikoerper, hedgehog acyltransferase like, b antikoerper, hedgehog acyltransferase like, a antikoerper, Hhatl antikoerper, hhatl.S antikoerper, HHATL antikoerper, hhatl antikoerper, hhatlb antikoerper, hhatla antikoerper

Hintergrund:

Synonyms: C3orf3, Glycerol uptake/transporter homolog, GUP1, GUP1 glycerol uptake/transporter homolog, Hedgehog acyltransferase like, Hedgehog acyltransferase-like protein, Hhatl, HHATL_HUMAN, KIAA1173, MBOAT3, Membrane bound O acyltransferase domain containing 3, MSTP002, OACT3, Protein-cysteine N-palmitoyltransferase HHAT-like protein.

Background: GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

Gen-ID: 57467

Pathways: Hedgehog Signalweg