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FYB Antikörper (AA 501-600) (AbBy Fluor® 555)

FYB Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN1697044
  • Target Alle FYB Antikörper anzeigen
    FYB (FYN-Binding Protein (FYB))
    Bindungsspezifität
    • 14
    • 12
    • 8
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600
    Reaktivität
    • 50
    • 8
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 42
    • 7
    • 1
    Kaninchen
    Klonalität
    • 43
    • 7
    Polyklonal
    Konjugat
    • 27
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FYB Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 35
    • 25
    • 12
    • 12
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FYB/ADAP
    Isotyp
    IgG
    Top Product
    Discover our top product FYB Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    FYB (FYN-Binding Protein (FYB))
    Andere Bezeichnung
    FYB/ADAP (FYB Produkte)
    Synonyme
    fyb antikoerper, ADAP antikoerper, PRO0823 antikoerper, SLAP-130 antikoerper, B630013F22Rik antikoerper, FYB-120/130 antikoerper, Slap130 antikoerper, p120/130 antikoerper, p120/p130 antikoerper, RGD1563421 antikoerper, FYN-binding protein antikoerper, FYN binding protein 1 antikoerper, FYN binding protein antikoerper, fyb antikoerper, FYB1 antikoerper, Fyb antikoerper, Fyb1 antikoerper
    Hintergrund

    Synonyms: ADAP, Adhesion and degranulation promoting adaptor protein, FYB 120/130, Fyb, FYB-120/130, FYB_HUMAN, FYN binding protein, FYN T binding protein, FYN-binding protein, FYN-T-binding protein, p120/p130, PRO0823, SLAP 130, SLAP-130, SLAP130, SLP 76 associated phosphoprotein, SLP-76-associated phosphoprotein, SLP76 associated phosphoprotein.

    Background: Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn (13). SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (13). SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY) (4,5). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain (1,2). SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation (6). The human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein (7).

    Gen-ID
    2533
    Pathways
    T-Zell Rezeptor Signalweg, Protein targeting to Nucleus
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