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EYA4 Antikörper (AA 301-400) (AbBy Fluor® 555)

EYA4 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN1697622
  • Target Alle EYA4 Antikörper anzeigen
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Bindungsspezifität
    • 14
    • 14
    • 8
    • 5
    • 4
    • 3
    • 2
    AA 301-400
    Reaktivität
    • 44
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 44
    Polyklonal
    Konjugat
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EYA4 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 23
    • 21
    • 17
    • 14
    • 12
    • 12
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EYA4
    Isotyp
    IgG
    Top Product
    Discover our top product EYA4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    EYA4 (Eyes Absent Homolog 4 (EYA4))
    Andere Bezeichnung
    EYA4 (EYA4 Produkte)
    Synonyme
    B130023L16Rik antikoerper, CMD1J antikoerper, DFNA10 antikoerper, EYA transcriptional coactivator and phosphatase 4 antikoerper, Eya4 antikoerper, EYA4 antikoerper
    Hintergrund

    Synonyms: CMD1J, Deafness, autosomal dominant 10, DFNA 10, DFNA10, dJ78N10.1 eyes absent Drosophila homolog 4, dJ78N10.1 eyes absent, EYA 4, eya4, EYA4_HUMAN, Eyes absent 4, Eyes absent homolog 4 Drosophila, Eyes absent homolog 4, HGNC:3522, OTTHUMP00000040267.

    Background: A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).

    Gen-ID
    2070
    Pathways
    Sensory Perception of Sound
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