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Clca3 Antikörper (AbBy Fluor® 555)

CLCA3 Reaktivität: Maus, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN1698002
  • Target Alle Clca3 (CLCA3) Produkte
    Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))
    Reaktivität
    • 14
    • 14
    • 1
    Maus, Ratte
    Wirt
    • 15
    Kaninchen
    Klonalität
    • 15
    Polyklonal
    Konjugat
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Clca3 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 15
    • 12
    • 12
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Mouse,Rat,Dog
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from mouse CLCA3
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Clca3 (CLCA3) (Epithelial Chloride Channel Protein (CLCA3))
    Andere Bezeichnung
    Clca3 (CLCA3 Produkte)
    Synonyme
    calcium-activated chloride channel antikoerper, LOC784768 antikoerper
    Hintergrund

    Synonyms: Calcium activated chloride channel 3, Calcium-activated chloride channel regulator family member 3, Chloride channel accessory 3 pseudogene, chloride channel calcium activated 3, Chloride channel calcium activated family member 3, Clca1, Clca2, CLCA3P, Gob 5, Gob-5, Gob5, hCLCA3, mCLCA3, MGC143984, MGC143985.

    Background: The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer, therefore CLCA2 is thought to act as a tumor suppressor in normal cells. CLCA3 (known as Clca3 in mouse) is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach.

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