EXTL3 Antikörper (AA 351-450) (AbBy Fluor® 647)

Produktnummer ABIN1699125

Produktdetails anti-EXTL3 Antikörper (AbBy Fluor® 647)

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Bindungsspezifität: AA 351-450

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXTL3 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXTL3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu EXTL3

Target: EXTL3 (Exostoses (Multiple)-Like 3 (EXTL3))

Andere Bezeichnung: EXTL3 (EXTL3 Produkte)

Synonyme: BcDNA:LD21192 antikoerper, Botv antikoerper, CG15110 antikoerper, DEXT3 antikoerper, DEXTL3 antikoerper, Dextl3 antikoerper, Dmel\\CG15110 antikoerper, Extl3 antikoerper, 2900009G18Rik antikoerper, AU040105 antikoerper, Ext1l antikoerper, mKIAA0519 antikoerper, BOTV antikoerper, EXTL1L antikoerper, EXTR1 antikoerper, REGR antikoerper, RPR antikoerper, Regr antikoerper, brother of tout-velu antikoerper, exostoses (multiple)-like 3 antikoerper, exostosin like glycosyltransferase 3 antikoerper, exostosin-like glycosyltransferase 3 antikoerper, botv antikoerper, Extl3 antikoerper, EXTL3 antikoerper

Hintergrund:

Synonyms: botv, DKFZp686C2342, Exostoses multiple-like 3, Exostoses-like 3, Exostosin-like 3, EXT-related protein 1, EXTL1L, EXTL3, EXTL3_HUMAN, EXTR1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA0519, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, REG, Reg receptor, REGR, RPR.

Background: EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.

Gen-ID: 2137

Pathways: Glycosaminoglycan Metabolic Process, ER-Nucleus Signaling