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TLE4 Antikörper (AA 681-773) (AbBy Fluor® 647)

TLE4 Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 647
Produktnummer ABIN1699571
  • Target Alle TLE4 Antikörper anzeigen
    TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
    Bindungsspezifität
    • 14
    • 10
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 681-773
    Reaktivität
    • 57
    • 19
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 53
    • 5
    Kaninchen
    Klonalität
    • 55
    • 3
    Polyklonal
    Konjugat
    • 24
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TLE4 Antikörper ist konjugiert mit AbBy Fluor® 647
    Applikation
    • 46
    • 25
    • 12
    • 12
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TLE4
    Isotyp
    IgG
    Top Product
    Discover our top product TLE4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
    Andere Bezeichnung
    TLE4 (TLE4 Produkte)
    Synonyme
    TLE4 antikoerper, NV17443 antikoerper, BCE-1 antikoerper, BCE1 antikoerper, E(spI) antikoerper, ESG antikoerper, ESG4 antikoerper, GRG4 antikoerper, Esp2 antikoerper, Grg4 antikoerper, XGrg-4 antikoerper, XTCF-4 antikoerper, Xgrg4 antikoerper, Xtle4 antikoerper, esg4 antikoerper, grg4 antikoerper, gro antikoerper, 5730411M05Rik antikoerper, AA792082 antikoerper, Bce-1 antikoerper, Bce1 antikoerper, ESTM13 antikoerper, ESTM14 antikoerper, X83332 antikoerper, X83333 antikoerper, transducin like enhancer of split 4 antikoerper, transducin-like enhancer protein 4 antikoerper, protein groucho-1 antikoerper, transducin-like enhancer of split 4 antikoerper, transducin like enhancer of split 4-Z 1 antikoerper, transducin like enhancer of split 4 S homeolog antikoerper, TLE4 antikoerper, LOC706619 antikoerper, LOC100117159 antikoerper, LOC100462498 antikoerper, Tle4 antikoerper, TLE4Z1 antikoerper, LOC476317 antikoerper, tle4.S antikoerper
    Hintergrund

    Synonyms: B lymphocyte gene 1, B lymphocyte gene 1, enhancer of split groucho 4, enhancer of split groucho 4, ESG4, ESG4, KIAA1261, TIM, TIM1, timeless Drosophila homolog, TLE4, transducin-like enhancer of split 4, transducin-like enhancer of split 4, TLE4_HUMAN.

    Background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.

    Gen-ID
    7091
    Pathways
    WNT Signalweg
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