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GRB7 Antikörper (AA 231-330) (Biotin)

GRB7 Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700331
  • Target Alle GRB7 Antikörper anzeigen
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-330
    Reaktivität
    • 58
    • 15
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 55
    • 3
    • 1
    • 1
    Kaninchen
    Klonalität
    • 59
    • 1
    Polyklonal
    Konjugat
    • 30
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GRB7 Antikörper ist konjugiert mit Biotin
    Applikation
    • 36
    • 26
    • 13
    • 13
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GRB7
    Isotyp
    IgG
    Top Product
    Discover our top product GRB7 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
    Andere Bezeichnung
    GRB7 (GRB7 Produkte)
    Synonyme
    GRB7 antikoerper, mKIAA4028 antikoerper, growth factor receptor bound protein 7 antikoerper, GRB7 antikoerper, Grb7 antikoerper
    Hintergrund

    Synonyms: B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7, OTTHUMP00000164349, OTTHUMP00000164350, OTTHUMP00000164351, OTTHUMP00000164352.

    Background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6).

    Pathways
    EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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